Lecture2

Lecture2 - S1 => S2? HIVP Drug => HIVP-Drug G= H - TS...

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S1 => S2? HIVP Drug => HIVP-Drug G= H - T S Drug-binding HIV means interactions => releases heat: - H => less freedom: - S How will changing temperature affect the situation?
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However, we need to think about where this is happening => not in a vacuum but in aqueous solution. We need to consider: water interactions with E, water interactions with D and entropy change of water, and amount of E and D vs. water
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YIKES 1: As the amount of E and D and E-D change, G will also change Another thing: we also need to think about what happens when we move from from S1 to S2 (this is where the dynamics come in) Somewhere along the way G=0 Equilibrium !! Now we need to compare G from S1 to point S1.1 We are also usually thinking about not just 1 molecule of E and 1 molecule of D forming 1 molecule of ED, but a whole population of these.
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http://www.chem1.com/acad/webtext/thermeq/TE4.html more E-D, less E and D
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Δ G° = –RT ln K K E = [E-D]/[E] [D] at equilibrium K E => equilibrium constant
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This note was uploaded on 01/17/2011 for the course BIOC 100A taught by Professor Harrynoller during the Fall '10 term at UCSC.

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Lecture2 - S1 => S2? HIVP Drug => HIVP-Drug G= H - TS...

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