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Lecture5

Lecture5 - The Department of Chemistry Biochemistry is...

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to announce The first Tony Fink Memorial Lecture entitled "Increasing Evidence that Prions Cause Most Neurodegenerative Diseases" by Nobel Laureate Stanley B. Prusiner Professor of Neurology, UCSF DATE:Friday, October 15 TIME:5:00 p.m. PLACE:Baskin Auditorium 101
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Protein folding: Thermodynamic stability Kinetic stability Proteins structure prediction - homology modeling - Fold-It - CASP Chaperones Diseases of mis-folding
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How do proteins become folded?
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Anfinsen's experiment: purified ribonuclease A => activity? incubate with 8 M urea and mercaptoethanol => activity? dialyze out urea in the presence of O 2 => activity? or incubate with O 2 , then dialyze out urea => activity?
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This data suggests that Ribonuclease A has: A. alpha helices B. beta sheets C. ionic bonds D. disulfide bonds
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Nobel prize winning conclusion:
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What makes folding spontaneous? G = H - T S H from: S from
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100 amino acid protein for each amino acid approximately ______ back bone conformations
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Lecture5 - The Department of Chemistry Biochemistry is...

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