Lecture8

Lecture8 - 25 26 The hammerhead ribozyme (plant virus)...

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1 UCSC Programs Abroad International Education Office University of California, Santa Cruz Programs Abroad Peer Advisor International Education Office 107 Classroom Unit Building (831)459-1686 (831)459-2382 fax programsabroad@ucsc.edu http://oie.ucsc.edu :
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2 iClicker roll call
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4 RNA structure and catalysis: RNA vs. DNA RNA as an information molecule RNA secondary structure RNA tertiary structure RNA as a catalyst RNA world
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6 The central dogma: information => chemistry
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7 RNA is more than a messenger:
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8 Hairpin Loops Stems Bulge loop Interior loops Multi-branched loop RNA secondary structure
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9 RNA tertiary structure: GO TO PYMOL
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21 The central dogma: information => chemistry conundrum: how did these pathways evolve in parallel?
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23 What is life? Multiplication Mutation Heredity properties that are required for a population to evolve by natural selection.
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24 Sn2 reaction main chemical reaction for nucleic acids: phosphodiester transfer
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Unformatted text preview: 25 26 The hammerhead ribozyme (plant virus) Martick & Scott, Cell 2006 27 Group I intron ribozyme Golden et al, and cech Science (1998) 28 Acid-Base catalysis ? G8 as a base A38 as an acid Bevilacqua, Biochemistry 2003 29 Wilson and Szostak, Ann.Rev.Bioc. (1999) SELEX: Systematic evolution of ligands by exponential amplification What can RNA bind / catalyze? 30 The ATP aptamer structure 31 These types of enzymes have been made! Limited polymerization RNA ligases RNA capping RNA phosphorylation RNA cleavage Peptide bond formation Amide bond formation 32 33 RNA World? 34 RNA structure and catalysis: RNA vs. DNA RNA as an information molecule RNA secondary structure RNA tertiary structure RNA as a catalyst RNA world 35 Have fun with Manny!...
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Lecture8 - 25 26 The hammerhead ribozyme (plant virus)...

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