ProblemSet1

ProblemSet1 - BIOC100A Problem Set # 1 1. Using the Gibbs...

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BIOC100A Problem Set # 1 1. Using the Gibbs free energy equation as a backdrop, explain why binding of a small molecule to a macromolecule is determined by a battle between enthalpy and entropy. 2. A. If you were given the change in enthalpy (a number we'll call X) and the change in entropy (a number we'll call Y) of 1 mole of drug binding to 1 mole of HIV protease, could you tell me whether that binding would happen spontaneously? If so, describe how in terms of X and Y. If not, what other information would you need? B. If I told you that the binding of drug and protease is happening in aqueous solution, would that change your answer to 2.A? If so, restate that answer in light of this information. If not, explain why not. 3. If making covalent bonds releases a lot of heat, propose a thermodyamic reason and a kinetic reason as to why we don't see spontaneous formation of ATP from a mixture of ADP and Pi in water. Rank those reasons in order of their relative importance. 4. If the equilibrium concentrations of ATP = 1x10
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ProblemSet1 - BIOC100A Problem Set # 1 1. Using the Gibbs...

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