ProblemSet2 - BIOC100A Problem Set # 2 1. Does pKa depend...

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BIOC100A Problem Set # 2 1. Does pKa depend on temperature? Why? 2. A. Subtilisin is a non-specific protease that is added to many household products such as laundry soap and contact lens cleaners. Given that proteases break peptide bonds, how could this protein be useful in these products? B. The structure of subtilisin is known (look at the subtilisin.pdb file in PyMol or RasMol and show the cartoon/secondary stucture. Sketch a secondary structure topology map of the protein. 3. List/sketch the four atoms that define the following dihedral angles. ω , ψ , φ 4. Hair grows at a rate of 15 to 20 cm/yr. All this growth is concentrated at the base of the hair fiber, where α -keratin filaments are synthesized inside living epidermal cells and assembled into ropelike structures. The fundamental structural element of α -keratin is the α helix, which has 3.6 amino acid residues per turn and a rise of 5.4 Å per turn. Assuming that the biosynthesis of α -helical keratin chains is the rate-limiting factor in the growth of hair, calculate the rate at which peptide bonds of α -keratin chains must be synthesized (peptide bonds per second) to account for the observed yearly growth of hair.
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This note was uploaded on 01/17/2011 for the course BIOC 100A taught by Professor Harrynoller during the Fall '10 term at University of California, Santa Cruz.

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ProblemSet2 - BIOC100A Problem Set # 2 1. Does pKa depend...

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