Metabolism-1

Metabolism-1 - CHEM 109C Zhang Stage (Location) Fats + 3...

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CHEM 109C – Zhang Metabolism Overview CLAS F10 Stage (Location) From our food… 1 Digestion (stomach & intestines) Fats Carbohydrates (glycogen, starch) Proteins + 3 H 2 O + H 2 O + H 2 O (Sect. 25.6, Fig 25.3) (Sect. 25.7, Fig 25.4) endo and exopeptidases O - O R 3 Fatty Acids OH OH O H Glycerol O H H H H O H OH H OH OH OH Glucose (monosaccharides) O NH 3 + O - Phe as example ( Amino Acids ) 2 Formation of Acetyl- CoA acyl-CoA synthase ↓ CoASH → ADP, HPO 4 2- glycerol kinase ↓ ATP, Mg 2+ → ADP hexokinase ↓ ATP, Mg 2+ → ADP phenylalanine hydroxylase SCoA O R fatty acid acyl-CoA (a thioester) OH OH PiO glycerol-3-phosphate O H H H H O H OH H OH OH OPi glucose-6-phosphate O NH 3 + O H O - Tyr acyl-CoA dehydrogenase ↓ FAD → FADH 2 phosphoglucose isomerase ↓↑ tyrosine aminotransferase ↓ PLP SCoA O R α,β -unsaturated fatty acid acyl-CoA O OH H O H OH H H PiO OH fructose-6-phosphate O O O H O - p-hydroxyphenylpyruvate enoyl-CoA hydratase ↓ H 2 O phosphofructokinase ↓ ATP, Mg 2+ → ADP p-hydroxyphenylpyruvate dioxygenase Know all mechanisms! Page 1 of 8
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CHEM 109C – Zhang Metabolism Overview CLAS F10 SCoA O R OH β -hydroxy fatty acid acyl-CoA O OH H O H OH H H PiO OPi fructose-1,6-diphosphate O O O H O - OH homogentisate 3-L-hydroxyacyl-CoA dehydrogenase ↓ NAD + → NADH, H + glycerol phosphate dehydrogenase ↓ NAD + → NADH, H + aldolase ↓↑ homogentisate dioxygenase SCoA O R O β -keto fatty acid acyl-CoA O O H OPi dihydroxyacetone phosphate (can enter glycolysis) O O H OPi O H OH PiO dihydroxyacetone t r i o s e p h o s p h a t e i s o m e r a s e glyceraldehyde-3- phosphate phosphate
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This note was uploaded on 01/17/2011 for the course CHEM 109C taught by Professor Bruice during the Fall '08 term at UCSB.

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Metabolism-1 - CHEM 109C Zhang Stage (Location) Fats + 3...

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