Lect18-KR - Lifestyles of the Small and Numerous PMB/MCB...

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Lifestyles of the Small and Numerous PMB/MCB 112 October 13, 2010
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Endospore formation or sporulation by Gram positive bacteria Most endospore-forming bacteria live in the soil and sporulate when nutrients are limiting Mature spores are dormant/metabolically inactive, and resistant to heat, dessication, chemicals, UV radiation Generated by asymmetric cell division, where one cell becomes the spore and the other cell helps to build the spore and then disintegrates
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How does Bacillus subtilis choose vegetative growth vs. sporulation?
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1 Intermediate Response regulator Histidine phospho- transferase 2 3 4 Histidine kinase(s) DNA-binding Response regulator Sporulation phosphorelay KinA, KinB Spo0F Spo0B Spo0A
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KinA KinB Spo0F Spo0B Spo0A KinA, KinB histidine kinases Spo0F response regulator Spo0B histidine phosphotransferase Spo0A response regulator Spo0A binds DNA and regulates ~120 genes involved in sporulation Commitment to sporulation requires high levels of Spo0A~P DNA damage GTP RapA Cell density Spo0E
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