Lec3-MWrev - PMB/MCB 112 Degradation of Xenobiotics Reading Minireview Degradation of Xenobiotics 1 Overview of xenobiotic degradation 1

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PMB/MCB 112 10/20/2010 Degradation of Xenobiotics Reading: Minireview
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1. Overview of xenobiotic degradation 1. Optimization of xenobiotic-degrading bacterial strains (e.g. PCBs) Intro to PCBs Optimization of PCB degradation Degradation of Xenobiotics
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Xenobiotic Biodegradation Xenobiotics: chemically synthesized compounds that are not naturally occurring Often these compounds are structurally similar to naturally occurring compounds Thus they can be slowly degraded by existing enzymes Now look at: Evolution, selection, optimization of bacteria that degrade prevalent contaminants For this, it is important to understand the genetics of xenobiotic degradation
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Xenobiotic Biodegradation Xenobiotics: chemically synthesized compounds that are not naturally occurring. * Includes pesticides, polychlorinated biphenyls (PCBs), munitions, dyes, chlorinated solvents * Persistence of these compounds can be weeks to years. Recalcitrant . Bioavailability Microbial degradation Volatilization, leaching, spontaneous chemical breakdown
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Bioremediation of PCBs Polychlorinated biphenyls (PCBs) 1-10 Cl atoms on a biphenyl carbon skeleton 20-60 different PCBs were present in commercial products Highly hydrophobic and very stable ---> persistent * Used extensively in electrical transformers to absorb heat * PCBs are endocrine inhibitors; they mimic natural hormones Severe problems for wildlife and humans In humans, can cause infertility, breast/prostrate cancer, neurological problems, etc. Bioaccumulate
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This note was uploaded on 01/19/2011 for the course C 112 taught by Professor Ryan during the Fall '10 term at University of California, Berkeley.

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Lec3-MWrev - PMB/MCB 112 Degradation of Xenobiotics Reading Minireview Degradation of Xenobiotics 1 Overview of xenobiotic degradation 1

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