Lecture 3 vaccines 2010

Lecture 3 vaccines 2010 - Lecture 3 Vaccines History of...

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Lecture 3 Vaccines
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History of Small Pox vaccination 500 AD : in China first described vaccination using dried material from human lesion 1700 : “Variolation” small pox lesion material is inoculated into arm 1776 : G. Washington orders variolation of his troops
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History of Small Pox vaccination “Variolation” Problem: some people get either very sick or die or actually start spreading small pox disease thus causing endemic outbreaks
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1798 Small Pox Vaccination Edward Jenner (1749-1823)
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History of Small Pox Vaccination The First Vaccine •Jenner is a country physician, learns about cowpox •Milkmaids who had previous cowpox infections never got small pox infections (“If you want to marry a woman who will never be scarred by the ‘POX” marry a milkmaid) •Uses material from cowpox lesions to inoculate “volunteers”, among them his 10-month old son and performs challenge experiments with virulent small pox (1796- 98) •Great success and procedure becomes commonly accepted immediately
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This note was uploaded on 01/24/2011 for the course BSCI 424 taught by Professor Staff during the Fall '08 term at Maryland.

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Lecture 3 vaccines 2010 - Lecture 3 Vaccines History of...

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