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Lecture 4 Central Dogma II- From RNA to Protein

Lecture 4 Central Dogma II- From RNA to Protein -...

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1 Announcements Lecture 4 Exam covers Lectures 1 to 6, and associated problems and readings. Note, not all lecture material is in the powerpoint slides Lectures 5 and 6 will be posted shortly Answers to the recommended odd-numbered problems from Essential Genetics are posted on the web site We will provide the scantron cards The hourly exams from previous years are posted No make-up exams
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2 The primary transcript is processed into mRNA in eukaryotes Exon 1 DNA Exon 2 Exon 3 Intron 1 Intron 2 Promoter Primary Transcript 5’ MeG cap Exon 1 Exon 2 Exon 3 Intron 1 Intron 2 AAA Transcription 5’ MeG cap Exon 1 Exon 2 Exon 3 AAA Splicing (introns spliced out) mRNA
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3 Gene Expression is Regulated Gene expression is highly regulated and cell type-specific Neuron-specific proteins are made in neurons but not in neutrophils. Regulation of gene expression can occur by the regulation of transcription, splicing, or translation Much of gene regulation occurs through the regulation of transcriptional initiation by the presence or absence of tissue-specific transcription factors
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4 Sample Questions (Lecture 3) 11. The muscle creatine kinase gene is expressed in muscle cells but not liver cells. Which of the following is the most likely explanation for this tissue- specific gene expression: (A) A muscle-specific transcription factor is found in muscle cells, but not liver cells (B) A muscle-specific enhancer element is found in muscle cells, but not liver cells (C)A muscle-specific 5’ splice junction is found in muscle cells, but not liver cells (D)A muscle-specific rRNA is found in muscle cells, but not liver cells (E) A muscle-specific DNA polymerase is found in muscle cells, but not liver cells
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5 Central Dogma II: From RNA to Protein Lecture 4 Bio Sci 97 (B & C) Fall 2010
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6 DNA to RNA to Protein
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7 4-7 Basics of Genetic Code Translation : translate information from RNA (DNA) sequence to protein sequence Universal (nearly) Amino acids are coded for by
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