8 - BIO 311C Fall 2010 Reminder: We will devote the last...

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BIO 311C Fall 2010 Lecture 8 – Friday 13 Sept. 2010 Reminder: We will devote the last ~20 minutes of next Wednesday’s lecture to a review of the subject matter of topics ro be covered on Exam 1. 1
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A Few of the Many Types of Intermediate Filaments that Occur in Higher Animal Cells Keratin: is the major component of skin cell cytoplasmic matrix; is the major component of hair and nails; is the main component of bird feathers. Neurofilaments: occur in the cytoplasmic matrix of nerve cells. Lamins: occur in nucleoplasm. 2
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Keratin intermediate filaments align in parallel within the cytoplasmic matrix of skin cells. They are concentrated at points where the cell is connected tightly to adjacent cells through anchoring junctions called desmosomes. keratin filament desmosome Skin cells continuously die and are replaced by new cells. The dead cells are completely destroyed, except for the keratin microfilaments, which remain as a surface coating on the outer layer of skin. Keratin is highly protective, since it is impenetrable to most solvents and inert to most chemical agents. skin cells See textbook Fig. 6.32, p. 121 3
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portion of a nerve cell The long strands running parallel to each other in this image are bundles of neurofilaments. Each neurofilament in the bundle is 10 nm in diamteter. Electron Microscope Picture of a Slice Through a Nerve Cell, Showing neurofilaments 4
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Fluorescent Stain of Lamin, Showing its Occurrence in the Nucleoplasm, Just Inside of the Nuclear Envelope Most kinds of Intermediate filaments occur in the cytoplasmic matrix. Lamin is an exception. 5
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Some ways that intermediate filaments are different from microfilaments and microtubules Microtubules and microfilaments are made of globular proteins while intermediate filaments are made of fibrous proteins. Microtubules and microfilaments are dynamic structures that can be quickly dis- assembled and re-assembled from their subunits by the cell. Intermediate filaments are very stable and most of them are not dis-assembled after they are formed. Microfilaments and microtubules perform a large variety of functions, many of which
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This note was uploaded on 01/21/2011 for the course BIO 311C taught by Professor Satasivian during the Fall '08 term at University of Texas at Austin.

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8 - BIO 311C Fall 2010 Reminder: We will devote the last...

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