exam_2a - microbial genetics

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1 Biology 638 – Biochemistry II Exam-2 (February 22, 2010) 1 . Select the statement that is not correct. a. In general, glucagon and epinephrine stimulate catabolism, while insulin stimulates anabolism. b. If the phosphorylation site Ser-14 of glycogen phosphorylase is mutated to Ala, this mutated enzyme will be inactive because there is no phosphorylation site. c. Glucagon stimulates glycogen breakdown in liver cells. d. Calmodulin is one of the subunits of phosphorylase kinase. e. Phosphorylation of regulatory subunits (α and β) and Ca 2+ binding to δ subunit activate the catalytic γ-subunit of phosphorylase kinase. 2 . Select the statement that is not correct. a. Phosphorylation of glycogen synthase is translated to inactivation of glycogen synthesis. b. Phosphorylation of phosphoprotein phosphatase inhibitor-1 is translated to inactivation of glycogen synthesis. c. Phosphorylation of G-subunit of phosphoprotein phosphatase-1 by protein kinase A is translated to activation of glycogen synthesis. d. High glucose concentration in liver cells is translated to activation of glycogen synthesis. e. High AMP concentration in muscle cells is translated to activation of glycogen breakdown. 3 . Select the statement that is not correct. Assume that PFK-2/FBPase-2 in heart muscle is suddenly changed to the liver isozyme when this person is sleeping. _____. a. This person would awake without any serious health problem b. This person would not be able to run c. This person would have slightly low blood glucose level d. This person would have low F2,6P level in heart muscle e. None of the above 4 . Select the statement that is not true. If glucokinase in liver is suddenly changed to hexokinase, ______. a. the glucagon concentration in blood would be increased b. the glucose concentration in blood would be decreased c. the glycogen breakdown in liver would be increased d. the G6P concentration in liver would be increased e. None of the above 5 . Select the statement that is not correct. a. A role of PLP in the glycogen phosphorylase reaction is proton donor. b. A role of PLP in the glycogen phosphorylase reaction is proton acceptor. c. PLP in glycogen phosphorylase is a coenzyme but not a prosthetic group. d. In the glycogen phosphorylase reaction, the cleaved glucose is stabilized by having a half- chair conformation. e. None of the above.
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This note was uploaded on 01/22/2011 for the course BIO 638 taught by Professor Arizumi,k during the Spring '10 term at Kansas.

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exam_2a - microbial genetics

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