EXAM _3 BIOL688 2009

EXAM _3 BIOL688 2009 - EXAM 3: Molecular Biology of Cancer...

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EXAM 3: Molecular Biology of Cancer 10 November 2009 Fill in the blank (1 point each blank) 1. List the 4 factors that Weinberg’s group introduced into primary human cells grown in culture resulting in their transformation ____________________, ___________________, ______________________, _____________________. How many steps are required to produce tumors in new born mice? More than _________. How many steps are required to experimentally transform mortal mouse fibroblast cells grown in culture? _________. 2. One example of apoptosis in adult organisms is ___________________________________ ____________________________________________________________. During apoptosis, cleavage of the cellular death substrate ______________________ results in chromatin condensation and nuclear shrinkage. The subcellular organelle ________________________ is involved in the intrinsic apoptotic pathway. ___________________ proteins are involved in both pathways of apoptosis and can be considered the central “engines” of apoptosis. The ____________________ family of proteins can be either pro- or anti-apoptotic and are considered the major regulators of apoptosis. What are three components of the apoptosome? ___________________, ___________________, and _________________________. 3. The __________________ excision repair pathway is defective in Xeroderma Pigmentosum patients. In error-free bypass, DNA pol η automatically inserts two __________ into the newly synthesized DNA strand across from a pyrimidine dimer. The mismatched nucleotides in MMR are recognized by the protein ________________. 4. The specific structure made by the telomere end is called______________________. What are two properties of the telomere DNA sequence? ______________________ and _____________________. Human__________________________ cells have longer telomeres than human ________________________ cells. Multiple choice (2 points each): 5. Which of the following statements about apoptosis is true? a.
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This note was uploaded on 01/22/2011 for the course BIO 688 taught by Professor Neufel during the Spring '10 term at Kansas.

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EXAM _3 BIOL688 2009 - EXAM 3: Molecular Biology of Cancer...

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