EXAM _4 BIOL688 2009

EXAM_4 BIOL688 2009 - EXAM 4 Molecular Biology of Cancer 8 December 2009 Fill in the blank(1 point each blank 1 is the soluble signal secreted by

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1 EXAM 4: Molecular Biology of Cancer 8 December 2009 Fill in the blank (1 point each blank): 1. _______________ is the soluble signal secreted by cells in a ______________ state that initiates angiogenesis. This signal is received by _______________ cells which form new blood vessels. 2. The Rip-Tag mouse model is a model for ________________ cancer that was used to demonstrate that tumors require _________________ for growth. The phenomenon that allows hyperplastic islet cells to progress to tumors is referred to as the ___________________ __________________ (two words, 1 pt.). 3. The most commons site of colon cancer metastasis is ____________________. It is likely that colon cancer cells get to this location by travel through the________________ _____________(2 words, 1 pt). Proteins that span the cellular membrane and indirectly link the actin cytoskeleton to proteins in the ECM are _____________________________. 4. The _________-receptor is a rational target for immuno therapy because it is expressed in most cancer cells. ___________________(name of drug) was developed based on this rationale and this drug inhibits the kinase activity of the receptor by competing with ___________. __________ (name of particular cancer) is one of the main targets of this therapy because this cancer is resistant to traditional therapy. 5. Inhibitors of ______________, which has an essential function in DNA repair, are currently under clinical testing in patients with mutations in _____________ (name of gene). 6. Name four extracellular matrix (ECM)/basement membrane proteins (4 points) 1. 2. 3. 4. Multiple choice (2 points each): 7. Which of the following statements regarding endothelial cells is false ? a. Secrete vascular endothelial growth factor to stimulate angiogenesis. b.
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This note was uploaded on 01/22/2011 for the course BIO 688 taught by Professor Neufel during the Spring '10 term at Kansas.

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EXAM_4 BIOL688 2009 - EXAM 4 Molecular Biology of Cancer 8 December 2009 Fill in the blank(1 point each blank 1 is the soluble signal secreted by

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