Ch_322b_24.07

Ch_322b_24.07 - The Primary Structure of Polypeptides and...

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The Primary Structure of Polypeptides and Proteins The primary structure is the simple covalent bonding in a polypeptide expressed as the sequence of amino acid residues. The primary structure does not take into account bond angles and other features that determine the true three-dimensional picture of a polypeptide or protein. The importance of the primary structure for function is shown with the two nonapeptides below that have similar structures. Oxytocin is found in animals and is responsible for contractions during childbirth, the giving of milk by cows, and the laying of eggs by chickens. Oxytocin from chickens is used to induce labor. Cys.Tyr.Ile.Gln.Asn.Cys.Pro.Leu.GlyNH 2 Cys.Tyr. Phe .Gln.Asn.Cys.Pro. Arg .GlyNH 2 Vasopressin is found in males and females and is secreted by the pituitary gland. It causes contraction of blood vessels and increases blood pressure. It also is an antidiuretic since it decreases the excretion of water by the kidney.
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These structural differences are shown below. oxytocin H 2 NGly Leu Pro Cys Asn Gln Ile Tyr Cys H 2 NCCH 2 NH CCHNH C O = O O CH 2 CH(CH 3 ) 2 N O C CHNH CCHNH O CH 2 C-NH 2 O C=O CHCH 2 CH 2 CNH 2 O NH C=O CHCHCH 2 CH 3 CH 3 NH CH 2 S S CHC O CH 2 OH NH CH 2 CH O=C H 2 N H 2 NCCH 2 NH CCHN H C O O CH 2 CH 2 CH 2 NHCNH 2 NH O N CHNH CCHNH
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Ch_322b_24.07 - The Primary Structure of Polypeptides and...

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