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Practice_Quiz_24_blank - equivalents of hydroxide has been...

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Practice Quiz 24 (1) Provide the products of the following reactions. (A) C 6 H 5 CH O = + NH 3 HCN + (i) H 3 O + /heat (ii) pH 7 CH 3 C-O-CNHCHCOOH CH 3 CH 3 O CH 2 C 6 H 5 + H 2 NCHC-OCH 2 C 6 H 5 O CH 3 + N=C=N THF provide all the products (C) (B) C 6 H 5 CH 2 CHCO 2 Et NH 2 + CH 3 C CH 3 CH 3 O C O CH 3 CH 3 CCH 3 O + t-BuOH + CO 2 C O O
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C C O = N CH COOEt COOEt (i) NaOEt (ii) C 6 H 5 CH 2 Br C 21 H 21 NO 6 O (2) Provide the missing structures in the following scheme. KOH/H 2 O heat (i) (ii) H 3 O + + COOH COOH C 9 H 12 N + X - heat (-CO 2 )
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Complete hydrolysis (3) Provide the products of the following reaction sequence. H 2 NCHCNHCHCNHCH 2 CO 2 CH 3 CH 2 C 6 H 5 O = O Ala.Phe.Gly at pH 8-9 O 2 N NO 2 + F
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(4) When an aqueous solution (pH ~ 1) of a simple α -amino acid, such as alanine (2-aminopropanoic acid), is titrated with a standard hydroxide solution, a titration curve (plot of pH vs. equivalents of base added) as shown below results. equivalents of HO - 0.5 1.0 1.5 2.0 pH 2 4 6 8 10 12 14 A B C (A) Provide structures inside the boxes for the species in solution at points A, B and C in the titration curve. D
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(B) What information is obtained from the titration curve where 0.5
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Unformatted text preview: equivalents of hydroxide has been added? Where 1.5 equivalents of hydroxide has been added? (C) What information is obtained at point D on the titration curve, an inflection point? (D) What is the isoelectric point? A complete hydrolysis H 3 O + , H 2 O, heat 2 Ala, 2 Gly, Phe, Ser, Tyr Van Slyke analysis NaNO 2 , H 3 O + , H 2 O, cold 0.001 mole of peptide yields 22.4 cc of N 2 (STP) Sanger labeling and then hydrolysis NO 2 O 2 N NHCHCOOH CH 3 unlabeled amino partial hydrolysis H 3 O + , H 2 O, heat Gly.Tyr Ala.Gly.Phe Ala.Ser.Gly Phe.Ala acids + (5) Structural analysis of an heptapeptide (A) gives the following results. What information is provided by the Van Slyke analysis? Sanger labeling experiment? Show how the partial hydrolysis results lead to the sequence for the heptapeptide. Provide the sequence in the shadow box below....
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This note was uploaded on 01/23/2011 for the course CHEM 322BL taught by Professor Singer during the Spring '07 term at USC.

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Practice_Quiz_24_blank - equivalents of hydroxide has been...

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