5_2_Cloning_stemcells - Hello, Dolly! Dollys lamb, bonnie...

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Hello, Dolly! Natural-born offspring Dolly’s lamb, bonnie Dolly, baby, and surrogate mother
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Mammalian cloning Need an egg! Nucleus came from differentiated cell Need a uterus!
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Why has cloning mammals become possible now? In vitro fertilization technology has come of age. Louise Brown the first “test tube baby” was born in the 1970s. Nuclear transfer into human eggs is possible for males with defective sperm. Cloning is an effective way of producing genetically engineered, designer animals.
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Somatic nuclear transfer Totipotency (the ability to differentiate into all different cell types) was regained when somatic cells were arrested in the cell cycle before DNA synthesis. De-differentiation Differentiation involves nuclear programming: Reversible modifications of some DNA bases; Cytosines are methylated. Chromatin is modified.
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Why Clone? Reproductive cloning is used to propagate genetically superior or genetically engineered trees, plants, and livestock.
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cloning? Dolly was the only lamb from 277 fused eggs
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This note was uploaded on 01/25/2011 for the course BIO 1510 taught by Professor Unknown during the Spring '07 term at Georgia Institute of Technology.

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5_2_Cloning_stemcells - Hello, Dolly! Dollys lamb, bonnie...

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