DSP4 MCDB27 - /Kosik 20:20 (AmyloidPrecurso

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Comparative Literature 27 – Jullien/Kosik 20:20 Senile plaques  – examined through a high-power electron microscope: Fibrils – conglomeration of proteins that form rope-like structures in the brain Beta-Amyloid protein – protein in the senile plaque Comes from parent protein – APP (Amyloid Precursor Protein) Enzymes cut APP protein   Beta-Amyloid protein aggregates = formation of  Beta-Amyloid Plaque Amyloid collects around and destroys synapses in the Alzheimer’s brain  Sundowner      – Alzheimer’s patients start to get disoriented at the end of the day –  frequently observed, thus far unexplained, phenomenon Amnesic patients with primary damage to the hippocampus bilaterally (on both  sides) were impaired in constructing new imaged experiences when given short  verbal cues about simple commonplace scenarios Impaired memory leads to difficulty imagining things Willem de Kooning – American artist who developed Alzheimer’s disease in his  later years Produced a complex painting while suffering from advanced Alzheimer’s Mild Cognitive Impairment All definitions share the feature of cognitive impairment that does not impair  instrumental activities of daily living (e.g. shopping, finances, cooking, household 
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This note was uploaded on 01/25/2011 for the course MCDB 31559 taught by Professor Kosik during the Winter '10 term at UCSB.

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DSP4 MCDB27 - /Kosik 20:20 (AmyloidPrecurso

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