hallucinogens - resemble LSD feelings of dissociation,...

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drug class mechanism of action LSD seratonin psilocybin seratonin lysergic acid seratonin MDMA blocks reuptake NMDA competitive noncompetitive: PCP smoked and snorted, not available orally ketamine MK-801 other: include ethanol, methadone, dextromethorphan oral, low toxicity, bind directly with some types of seratonin receptors binds directly with some types of seratonin receptors oral or snorted because tasteless, iv and im medically
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effects excite SNS, halucinogenic trips, flashback, less potent then LSD, more visual hallucinations, less panic low potency, depression, anxiety, physically sick such as vomitting hyperthermia, low doses: tension in lower jaw. High doses:
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Unformatted text preview: resemble LSD feelings of dissociation, hallucinations, decrease memory, agitation, anxiety, aggression animal anesthetic, treat opiate withdrawl, reduce brain damage, antitussive, rat model of schiz long term cross tolerance with LSD effects after 30-60 minutes, 12 hour duration, half life 3 hrs, low addiction, low addiction, dopamine rush within 1 hr, duration 2-3 hours duration of 11-51 hours, no metabolites, tolerance due to environment and increasing NMDA receptors half life 1-3 hours, two active metabolites including norketamine, dehydronorketamine,...
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This note was uploaded on 01/26/2011 for the course NROSCI 0081 taught by Professor Armandosignore during the Fall '08 term at Pittsburgh.

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hallucinogens - resemble LSD feelings of dissociation,...

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