07 - Eugenol Derivative

07 - Eugenol Derivative - Preparation of Eugenol Benzoate...

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Unformatted text preview: Preparation of Eugenol Benzoate But first, a friendly reminder: Wear them! It's the LAW Preparation of Eugenol Benzoate eugenol benzoyl chloride eugenol benzoate Convert the eugenol present in clove oil to its benzoate ester: + NaCl Reaction Mechanism + NaCl Reaction Mechanism Experimental Procedure Step 1 Acid/Base Reaction- Add 1 mL of water to the centrifuge tube and then add 1M NaOH , drop by drop , just until the oil dissolves. The solution may be cloudy, but no oil droplets should be visible. (Water soluble) + Other Compounds (Ether soluble)- Transfer 0.2 mL of your clove oil into a clean, dry centrifuge tube. Step 2 - Extraction of Salt Discard in ether waste bottle KEEP IT!!!! 3 mL Aqueous layer ( KEEP IT! ) Ether layer Remove it! Experimental Procedure Add 4-5 drops of benzoyl chloride to the centrifuge tube IN THE HOOD . Stopper and shake mixture thoroughly. Remove stopper and warm mixture for 5 minutes in hot water bath . Use water aspiration to remove noxious fumes during heating. (Your TA will show you how to set up a pipet aspirator.) After cooling, add 2 mL of ETHER to the centrifuge tube and shake....
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This note was uploaded on 01/23/2011 for the course CHEM 3221 taught by Professor Bean during the Fall '08 term at University of Houston.

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07 - Eugenol Derivative - Preparation of Eugenol Benzoate...

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