08 - Reactivity of Alkyl Halides

08 - Reactivity of Alkyl Halides - Possible products...

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Nucleophilic Substitutions (S N 1, S N 2) of Halides
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S N 1 reaction: Carbocation stability is important factor. Polar, protic solvents such as ethanol support carbocation formation (stabilize transition state). Aprotic solvents such as acetone do NOT support carbocation formation. Weak nucleophile is OK.
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S N 2 reaction: Steric factors are important. Polar aprotic solvents increase rate of SN2. Aprotic solvent destabilizes nucleophile (increase its reactivity). Strong nucleophile necessary. The nature of the leaving group is important in both S N 1 and S N 2 reactions.
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Experiment Structural Effects: Possible products 0.2 mL(4 drops)
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Unformatted text preview: Possible products Experiment-You will have 2 series of 5 test tubes with 0.2 mL (4 drops) of each reactant. -You will monitor time for cloudiness. -If NaI/acetones do not react after 30 min, heat to 50 C in water bath (loose cork!!!)-If 95% EtOH/AgNO 3 tubes do not react after 30 min, also heat to 50 C . Post lab questions ;- Omit C- In d) change vinyl to aryl All Students must include statements in their lab reports about the following: 1. Alkyl halide structure and SN2 2. Alkyl halide structure and SN1 3. The leaving group 4. Aryl halide reactivity 5. Temperature and rate...
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08 - Reactivity of Alkyl Halides - Possible products...

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