11 - Grignard Reaction

11 - Grignard Reaction - Francois Auguste Victor Grignard...

Info iconThis preview shows pages 1–7. Sign up to view the full content.

View Full Document Right Arrow Icon
Francois Auguste Victor Grignard 1875-1935 Nobel Prize in Chemistry 1912 "for the discovery of the so-called Grignard reagent, which in recent years has greatly advanced the progress of organic chemistry"
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
The Grignard Reaction 1. A Grignard reagent is capable of reacting with many different substrates such as carbonyl compounds, alkyl halides and other organometallic reagents. 2. The addition of Grignard reagents to carbonyl compounds such a aldehydes, ketones, and esters yields the corresponding secondary and tertiary alcohols . 3. The Grignard reaction results in the formation of a carbon-carbon bond . 4. Grignard reagents are extremely strong bases that can react violently with hydroxylic compounds such as water or alcohols: R -MgX + H 2 O R-H (alkane) + BrMgOH + heat
Background image of page 2
Reaction of RMgX with Various Electrophiles
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Reaction of RMgX with Carbonyl Compounds
Background image of page 4
Synthesis of Triphenylmethanol Br Mg + MgBr + O OMe OH dry ether then, H + H +
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Tips for Ensuring Decent Yields 1. The Grignard reagent is very sensitive to mildly acidic protons (e.g. H 2 O and
Background image of page 6
Image of page 7
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

Page1 / 12

11 - Grignard Reaction - Francois Auguste Victor Grignard...

This preview shows document pages 1 - 7. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online