Lecture+4+Chemical+hazards

Lecture+4+Chemical+hazards - Drop boxes LOCATION CHANGE The...

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Unformatted text preview: Drop boxes LOCATION CHANGE The drop boxes are now located outside of SW511A (NOT on the sixth floor, SW644, as noted in the assignment) Midterm is on Saturday June 19th 9-10am in GYM Chemical Hazards and Human Health Chemical Hazards Endocrine disrupters Chemical body burdens Data mostly from animal studies, not much from human exposure Endocrine disrupters 1. Direct effects : Bind to hormone receptors Alter the appearance of some genes Changes in the level of produced proteins 2. Indirect effects: Altering hormone production Altering hormone transport Altering hormone metabolism Fetus more sensitive than adults DES (diethylstilbesteol) Synthetic estrogen used by physicians to prevent spontaneous abortion (1948-1971) Administered for early pregnancy until 35 weeks > 1million women took it between 1960-1970 Daughters whose mothers took DES have increased incidents of : Reproductive organ dysfunction Abnormal pregnancies Reduction in fertility Immune system disorders Carcinoma Endocrine disrupters - Health Implications Feminization of males Abnormal sexual behavior Birth defects Altered time to puberty Cancer of mammary glands or testis Thyroid dysfunction Endocrine disrupters – Neurobehavioral effects Prenatal and early postnatal exposures PCBs: Impaired learning in nonhuman primates Delayed psychomotor development Distractibility Poor IQ tests Organophosphates - Brain development Chemical body burdens Quantity of chemicals accumulated in the body Not stable over time Not distributed homogeneously in a body Not possible to detect if present in very low concentrations Biomonitoring – “normal level” Organochlorine Substances Dioxins DDT Dioxins...
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This note was uploaded on 01/25/2011 for the course EESA 10 taught by Professor Dr.silvijastefanovic during the Summer '10 term at University of Toronto.

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Lecture+4+Chemical+hazards - Drop boxes LOCATION CHANGE The...

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