ESS2 6 - Genetic Factors Contributing to Addiction Danielle...

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Danielle Sharaga Genetic Factors Contributing to Addiction
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Why should we care? Most of us know or have known someone who suffered from addiction. According to the National Institute on Drug Abuse addiction costs the nation $484 billion dollars, three times as much that is spent because of cancer. Finding genetic factors can hopefully lead to better treatments
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How do drugs work? Mimic or disrupt natural chemicals Dopamine reward pathway Pat Pathway (VRP)
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Dopamine reward pathway -Released from the amygdala even after only anticipating the drug -Stop/satiation pathway -damaged in addicts -After drug is used -> more dopamine is released -> do it again signal
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How drugs work cont. (Example: Cocaine) <-Blockage of DAT1 Genetic Difference -> increased expression of DAT1-> predisposition to cocaine addiction Repeated/high doses over time is a function of addiction (CNS forum)
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interest Mice are more attracted to cocaine and alcohol if they lack Htr1b. Increased expression of
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This note was uploaded on 01/25/2011 for the course ESS 20305 taught by Professor Powell during the Winter '10 term at UCSB.

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ESS2 6 - Genetic Factors Contributing to Addiction Danielle...

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