lec24+2010a - Unit VII Development Lecture 24 Genetic basis...

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Unit VII: Development Lecture 24: Genetic basis of development Lecture 25: Vertebrate Development I Lecture 26: Vertebrate Development II
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Reading Chapter 18: 412-425, Chapter 21 445-446. 24-1 Lecture 24: The Genetic Basis of Development Fall 2010, Bio 93, O’Dowd and Warrior, UCI - Copyright: All rights reserved Friday 11/19/10
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How do you go from zygote to mature individual? Human zygote 24-2 Fall 2010, Bio 93, O’Dowd and Warrior, UCI - Copyright: All rights reserved Gametes are haploid cells formed during meiosis Gametes fuse at fertilization to form a single diploid cell (zygote) Zygote divides by mitosis to form 2, 4, 8 ….. Millions to billions of cells that makes up the organism
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Four processes transform the zygote into the adult 1. Proliferation: Cell division 1. Differentiation: Different genes are turned on in different cells 1. Morphogenesis: Cells move to the appropriate locations and the organism’s shape is formed 1. Apoptosis: Regulated cell death 24-3 Fall 2010, Bio 93, O’Dowd and Warrior, UCI - Copyright: All rights reserved
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Drosophila melanogaster (Fruitfly) Caenorhabditis elegans (Nematode) Danio rerio, (Zebrafish), Vertebrate Mus musculus (Mouse), mammal Model systems to study animal development 24-4 Fall 2010, Bio 93, O’Dowd and Warrior, UCI - Copyright: All rights reserved
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Differentiation and Morphogenesis during Drosophila development Hierarchy of Gene Activity Maternal effect genes (egg-polarity genes) Gap genes Pair-rule genes Segment polarity genes
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