APchapter16notes - C hapte 16 Note r s TheMole cular Basis...

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Chapter 16 Notes TheMolecular Basis of Inheritance
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Concept 16.1 Once Morgan showed that genes are  located on chromosomes, DNA and  proteins  became the candidates for the  genetic material. - at the time nucleic acids seemed too  uniform to be responsible for the  multitude of possible traits.
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Concept 16.1 The role of DNA in heredity was first studied  by using bacteria and viruses. Griffith  (1928) was studying  streptococcus  pneumonia . - used 2 strains (pathogenic and  harmless)
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Concept 16.1
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Concept 16.1 - Griffith found that when he killed the  pathogenic bacteria with heat and then  mixed the cell remains with living  bacteria of the harmless strain, some of  the living cells were converted into the  pathogenic form.
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Concept 16.1 Transformation : a change in genotype  and phenotype due to the assimilation of  external DNA by a cell. Avery  (1944) purified various chemicals  from the heat killed bacteria to recreate  Griffith’s experiment.  Only DNA worked .
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Concept 16.1
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