December 11th Lecture Notes

December 11th Lecture Notes - Bioinformatics. Oncogenes You...

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Bioinformatics…. Oncogenes You can get hepititus B with recombinant DNA technology. There is a great use in forensics. Structural genes- (for proteins) are almost identical from people to people. In addition to tructural DNA, we don’t even know what it does, but it does vary a lot. (sometimes called junk DNA… and Individuals vary a lot in this DNA… so you know that you inherit a lot of your junk DNA from your parents) To see their junk. . you have to cut their DNA with the same enzyme. Then you project it in something called Electrophoresis. This separates the DNA by the fragments that was created when you put in the enzyme. What you do is put the DNA in the gel that has been treated by the enzyme… into the one end of the electrophoresis, and then you apply electrical current and according to the size and weight of the fragments they migrate onto the slate and show up as blobs in respective places. And then if you look at the children and mother and father blobs. . the blobs on the children show up in at least one of the parents. (testing for DNA of an individual) Mitochondrial DNA only comes from the Mother into the children. (look this up) National Geographic Channel has a project known as Genographic Project if you are are a girl then you are tested through the mitochondrial DNA and if you are a guy then you are tested through the Y chromosome. Then they tell you where you migrated from and where your family history came from. This is all being gathered and put in a database. How else is this recombinant DNA technology being used?? There are a couple of different ways of obtaining Material to do a test… 1. amniocentesis… what you do is get fluid from the fluid surrounding the fetus. Now into the ambionic fluid, cells are just broke off into the fluid. This is prenatal diagnosis. 2. CVS CHORIONIC VILLUS SAMPLING. Sample of the placenta is taken. There is partial tissue that is identical of the fetus and others that is different. These cells are rapidly growing cells. And you get them to grow really easily. Just like to other one, you are allowed to get a lot of DNA and do karyotyping and etc. Then with this technology, things called Transgenic Organism
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This note was uploaded on 04/04/2008 for the course BIO 101 taught by Professor Martin during the Fall '08 term at Rutgers.

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December 11th Lecture Notes - Bioinformatics. Oncogenes You...

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