final presentation - Presented by: Dmitriy Shegelman BI ONB...

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Unformatted text preview: Presented by: Dmitriy Shegelman BI ONB 4270 Paul W. Sherman Allergies and Bladder Cancer: A Search For The Fundamental Link Ur inar y Bladder canceR: morbidity & mor tality in the U.S. National Cancer I nstitute predicts over 70,000 new cases in 2010 Males compose over 70% of the expect ed new cases (NI H 2010) Despite 5-year-sur vival rates of almost 80%, bladder cancer is predicted to be the cause of more than 14,000 deaths in 2010 High social costs (including treatment cost and productivity loss), and potential for an innovation to yield large phar ma pr ofits Yet, the specific pathways and biomolecular inter actions behind the cause(s) of bladder cancer (mostly) remain a myster y Specific pathways are better understood, but why are allergies evolutionar ily maintained ? Evolution-based explanations are not even common practice yet: 2/3 of Amer icans still cling to their belief in Creationism! A quest inspir ed by Paul W. Sher man and his study showing cor relation between cancer and allergies (Sher man et al. 2008) An inver se cor r elation between allergies and bladder cancer was found, leading to suggestion of allergies being cancer preventers But How are allergies involved? Three suggestions attempt t o explain the obser ved link between cancer and allergies (Sher man et al. 2008): Antigenic Stimulation H ypothesis...
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This note was uploaded on 01/26/2011 for the course BIONB 4270 at Cornell University (Engineering School).

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final presentation - Presented by: Dmitriy Shegelman BI ONB...

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