Lecture_3 - Amino Acids • Peptide bond • Structure of...

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Unformatted text preview: Amino Acids • Peptide bond • Structure of 20 amino acids • Disulfide bond • Configuration and conformation • Nonstandard and biologically active amino acids Learning Objectives eneral Structure • All proteins are composed of 20 “standard” amino acids R | H 2 N – C α – COOH | H General structure of an α-amino acid. The R groups differentiate the 20 standard amino acids R | H 3 N + – C α – COO- | H At physiological pH, the amino group is protonated and the carboxylic group is unprotonated. Such molecules are called zwitterions or dipolar ions eptide Bond • Amino acids can be polymerized. Elimination of water molecule (condensation) produces a dipeptide H 3 N +-CHR ’-COO- + H 3 N +-CHR ”-COO- H 3 N +-CHR ’-CO-NH-CHR ”-COO- H 2 O peptide bond amino terminus or N-terminus carboxyl terminus or C-terminus • Dipeptide, tripeptide, … oligopeptide, … polypeptide, protein amino acid residue mino Acids One- and Three-Letter Codes A Ala Alanine L Leu Leucine...
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This note was uploaded on 01/27/2011 for the course BIOCH 2EE3 taught by Professor Zhorovb during the Spring '10 term at McMaster University.

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Lecture_3 - Amino Acids • Peptide bond • Structure of...

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