Lecture_4 - Proteins Learning Objectives Primary,...

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Proteins • Structure of collagen, a fibrous protein • Primary, secondary, tertiary, and quaternary structure • Location of polar and nonpolar residues in globular proteins • Myoglobin • Hemoglobin and sickle-cell anemia Learning Objectives
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Primary Structure • A protein has tens to thousands of amino acid residues • 100 amino acid residues may be combined in 20 100 10 130 different sequences (the universe has 10 79 atoms) DTASDAAAAAALTAANAKAAAELTAANAAAAAAATAR • Primary structure of a protein is the amino acid sequence of its polypeptide chain. For example, the primary structure of an antifreeze protein in one-letter code is: • The primary structure determines properties of a protein, while the amino acid composition is relatively not important (compare word atom and its anagram moat ) • Each protein consists of one ore more polypeptide chains
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Protein Structure Levels Figure 6-1 .
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Secondary Structure • Secondary structure refers to a spatial arrangement of the backbone without regard to the side chain conformations α α -Helix . Backbone carbonyl C=O of the residue N accepts H-bond from the backbone N-H group of the residue N+4 ( Fig. 6-8 ).
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Structure β -sheets are stabilized by H-bonds between two parallel backbones. In the parallel β -sheet, the backbones extend in the same directions. In the
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This note was uploaded on 01/27/2011 for the course BIOCH 2EE3 taught by Professor Zhorovb during the Spring '10 term at McMaster University.

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Lecture_4 - Proteins Learning Objectives Primary,...

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