Lecture_D - Ion Channels Learning Objectives Active and...

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Ion Channels • Ligand-gated Ion Channels • KcsA and mechanisms of ion permeation Learning Objectives • Voltage-gated Ion Channels • Blockers of Ion channels • Active and Passive Transport of Ions
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Ion Carriers and Ion Channels Fig. 10-1
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Valinomycin Fig. 10-2 Fig. 10-3
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Gramicidin A Fig. 10-5
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KcsA, a Bacterial K + channel Fig. 10-7
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The Permeation Pathway Fig. 10-7B
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The Mechanism of Ion Permeation Fig. 10-7C Fig. 10-8
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Nicotinic Acetylcholine Receptor http://www.chm.bris.ac.uk/org/gallagher/nAChR.gif
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Ligand-Gated Ion Channels • Example: nicotinic acetylcholine receptor. Agonist: acetylcholine. Antagonists: bungarotoxin, tubocurarine, myorelaxants Agonist binding site Receptor contains 5 pseudo- symmetric subunits One subunit has 4 transmembrane helices Top View Side View
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Bungarotoxin IVCHTTATSP ISAVTCPPGE NLCYRKMWCD AFCSSRGKVV ELGCAATCPS KKPYEEVTCC STDKCNPHPK QRPG
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d-tubocurarine is one of the active components of the arrow poison (curare) of South American Indians. Iban tribesman, former headhunters, positions to
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Lecture_D - Ion Channels Learning Objectives Active and...

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