Lecture_I - lycogen Metabolism and Gluconeogenesis •...

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Unformatted text preview: lycogen Metabolism and Gluconeogenesis • Glycogen structure • Glycogen breakdown • Glycogen synthesis Learning Objectives • Synthesis of glucose • Enzymes catalyzing glycogen breakdown Glucose Storage and Synthesis • Brain, red blood cells and some other tissues depend almost entirely on glucose as the source of energy • Glycogen is the stockpile of glucose for later metabolic use • A constant concentration of glucose in blood (~ 5 mM) is provided by glycogen mobilization Glucose Storage and Synthesis • Mobilization of glucose from glycogen occurs primarily in the liver • After the meal, glucose is plentiful. Glycogen is synthesized • Liver glycogen can supply brain and erythrocytes with glucose for ~ 12 hours • Under fasting conditions, glucose is synthesized from noncarbohydrate precursors (e.g., amino acids) – gluconeogenesis Overview of Glucose Metabolism Fig. 15-1 G6P is produced by:- phosphorylation of free glucose- glycogen degradation- gluconeogenesis he Structure of Glycogen Fig. 15-2 • Reducing end: the sugar whose...
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This note was uploaded on 01/27/2011 for the course BIOCH 2EE3 taught by Professor Zhorovb during the Spring '10 term at McMaster University.

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Lecture_I - lycogen Metabolism and Gluconeogenesis •...

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