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Lecture_J - Citric Acid Cycle Part I Learning Objectives...

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Citric Acid Cycle. Part I. • General features of the citric acid cycle • The hub of intermediary metabolism • Pyruvate dehydrogenase multienzyme complex Learning Objectives
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Overview • In aerobic organisms, metabolic fuels are oxidized in the citric acid cycle. • The citric acid cycle is a central pathway for obtaining energy from carbohydrates, fatty acids, and amino acids. Before entering the citric acid cycle, the metabolic fuels are decomposed and transformed to two-carbon acetyl groups -CO-CH 3 . The acetyl groups are attached to CoA to form acetyl-CoA. • Figure 16-1. • Intermediates of the citric acid cycle contain four to six carbon atoms and one to three carboxylic groups.
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Oxidative Fuel Metabolism Acetyl groups derived from carbohydrates, amino acids, and fatty acids, enter the citric acids cycle. In the Citric acid cycle, the acetyl groups are oxidized to CO 2 Fig. 16-1
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The Reactions of the Citric Acid Cycle • The net reaction of the citric acid cycle: 3 NAD + + FAD + GDP + P i + acetyl-CoA 3 NADH + FADH 2 + GTP + CoA + 2 CO 2 • Citrate, the product of the first step of the cycle has six carbons . • Oxaloacetate, the product of the last step, has four carbons . • The citric acid cycle is a series of
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Lecture_J - Citric Acid Cycle Part I Learning Objectives...

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