Lecture_M - Oxidative Phosphorylation Learning Objectives...

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Oxidative Phosphorylation • Structure of ATP synthase • Chemiosmotic theory Learning Objectives • Enzyme complexes in the electron transport chain
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Electron Transport in Mitochondria NADH NAD + Complex I 2e - Succinate FADH 2 Fumarate 2e - Complex II CoQ Complex III Complex IV Cytochrome c 2H + +1/2 O 2 H 2 O 2e - G 0' -70 kJ/mol G 0' -37 kJ/mol G 0' -112 kJ/mol
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Complex I: NADH-CoQ Oxidoreductase • Catalyses oxidation of NADH coupled to the reduction of CoQ: • The largest protein complex in the mitochondrial membrane. Contains 43 polypeptides. • Contains seven redox centers: FMN and 6 iron-sulfur clusters. • Electrons pass between the centers in the stepwise fashion.
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Complex I: NADH-CoQ Oxidoreductase • NADH donated two-electrons. Cytochrome c can accept only one electron. CoQ can transfer one or two electrons. • The electrons transfer between the 7 redox centers is coupled to pumping four protons out of the matrix. The detailed mechanism of proton pumping remains unknown.
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Complex II: Succinate-CoQ Oxidoreductase • This complex contains succinate
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Lecture_M - Oxidative Phosphorylation Learning Objectives...

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