Lecture_Q - Lipid Metabolism. Part III. Learning Objectives...

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Lipid Metabolism. Part III. • Control of glycogen and fatty acid metabolism • Functions of cholesterol • Control of cholesterol level Learning Objectives • Synthesis and transport of cholesterol • Cholesterol and Atherosclerosis
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Summary of Lipid Metabolism Fig. 19-31
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Blood Glucose, Glucagon and Insulin • Major energy reserves of the organism: - glycogen (liver) - triacylglycerols (adipose tissue) • Glucose concentration in blood is the major indicator of energetic and dietary state of the organism. • Sensors of glucose concentration: pancreatic α -cells and β -cells . - α -cells secrete hormone glucagon if [glucose] is low - β -cells secrete hormone insulin if [glucose] is high • Glucagon and insulin regulate glycogen and fatty acid metabolism. Major energy metabolites Carriers in blood Triacylglycerols Chylomicrons and VLDL Fatty acids Albumin Glucose, Ketone bodies, Lactate
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Control of Glycogen Metabolism Pancreatic hormone Glucagon Insulin (muscle) “Emergency” hormone
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Lecture_Q - Lipid Metabolism. Part III. Learning Objectives...

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