Lecture_K - Citric Acid Cycle. Part II Learning Objectives...

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Citric Acid Cycle. Part II • Regulation of the citric acid cycle • Eight reactions and eight enzymes of the citric acid cycle •ATP energy equivalent released in glucose catabolism • Metabolic reactions related to the citric acid cycle Learning Objectives
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1. Citrate Synthase COO - C=O CH 2 COO - HO-C-COO - COO - CH 2 CH 2 COO - Oxaloacetate Citrate + CH 3 -C(O)-S-CoA Acetyl-CoA H 2 O HS-CoA • Catalyzes the condensation of Acetyl- CoA and oxaloacetate • The initial reaction of the citric acid cycle • Carbon atoms from carbohydrates, fatty acids, and amino acids enter the cycle in the form of acetyl group attached to CoA. G 0' -32 kJ/mol
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2. Aconitase HO-C-COO - COO - CH 2 CH 2 COO - Citrate H 2 O C-COO - COO - CH 2 CH COO - H-C-COO - COO - CH 2 HO-C-H COO - cis -Aconitate Isocitrate H 2 O • Aconitase catalyzes the reversible isomerization of citrate and isocitrate, with cis -aconitate as an intermediate. • The hydration of the double bond of cis-aconitate could yield four stereoisomers. The enzyme catalyzes synthesis of only one isomer, isocitrate.
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3. NAD + -Dependent Isocitrate Dehydrogenase H + H-C- COO - COO - CH 2 C=O COO - H-C-H COO - CH 2 C=O COO - Oxalosuccinate α -Ketoglutarate NAD + H-C- COO - COO - CH 2 HO-C-H COO - Isocitrate NADH + H + H-C COO - CH 2 C-O - COO - CO 2 • The enzyme catalyzes the oxidative decarboxylation of isocitrate to
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This note was uploaded on 01/27/2011 for the course BIOCH 2EE3 taught by Professor Zhorovb during the Spring '10 term at McMaster University.

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Lecture_K - Citric Acid Cycle. Part II Learning Objectives...

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