Lecture_P - Lipid Metabolism. Part II. Learning Objectives...

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Lipid Metabolism. Part II. • Transport of fatty acids in the mitochondrion • Oxidation of fatty acids β -Oxidation • Ketone bodies • Biosynthesis of fatty acids Learning Objectives
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Oxidation of Fatty Acids • Triacylglycerols stored in adipocytes are mobilized by hormone- sensitive lipase. • Free fatty acids are released to the bloodstream, where they bind to a simple water-soluble protein albumin . • Before being oxidized, fatty acids are activated in the cytosol by combining with CoA: Fatty acid + CoA + ATP Fatty acyl-CoA + AMP +PP i • Example: fatty acid CH 3 -(CH 2 ) 14 -COO - fatty acyl-CoA CH 3 -(CH 2 ) 14 -C(O)-SCoA
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Carnitine : (CH 3 ) 3 N + -CH 2 -CH(OH)-CH 2 -COO - Fig. 19-11 Transport of Fatty Acids into the Mitochondrion
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Fig. 19-12 β -Oxidation • A sequence of four reactions in the mitochondrial matrix cuts off two-carbon units. • Fatty acyl-CoA: CH 3 -(CH 2 ) n -C β H 2 -C α H 2 -C(O)-S-CoA • The process is called β -oxidation because the cleavage takes place at β - carbon, which becomes the carboxyl carbon at the next round.
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Fig. 19-12 β -Oxidation • Oxidation of
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Lecture_P - Lipid Metabolism. Part II. Learning Objectives...

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