Chapter 15 - Chapter 15: Cell Signaling and Communication...

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Chapter 15: Cell Signaling and Communication I. Signals from Physical Environment a. Sense organs – light, odors, tastes, temp, touch and sound b. Receive from i. Other cells via extracellular fluid ii. Concentration gradients c. Autocrine signals i. Diffuse to cells d. Paracrine signals i. Diffuse near cells e. Hormones i. Circulatory system ii. Travel far f. Target cell – signal reaches target cell to respond by changing cell II. Signal Transduction Pathway – signaling process a. Receptor protein i. Concentration/signal changes shape of receptor ii. Shape change reveals active site = protein kinase iii. Protein kinase – enzyme that phosphorylates itself by stealing a phosphate group from ATP b. Responder i. Shape change due to charged phosphate ii. Binds to 2 nd protein (steals phosphate) iii. Shape change in 2 nd protein 1. Signal is transduced – completely in cell 2. Responder = activated a. Can cause effect 3. Signal amplified – one enzyme catalyzes many substrates conversions c. Transcription factor activated d. Specific protein synthesis activated e. Changes cell activity III. Receptors a. HIGHLY SPECIFIC b. Ligand – molecule binding to receptor site; Reversible binding i. Cytoplasmic receptors – small/nonpolar ligands diffuse through
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This note was uploaded on 01/27/2011 for the course BIOSC 0150 taught by Professor Lydiadaniels during the Fall '08 term at Pittsburgh.

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Chapter 15 - Chapter 15: Cell Signaling and Communication...

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