Glycolysis and Fermentation Notes

Glycolysis and Fermentation Notes - VI.Logic of Glycolysis...

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Glycolysis and Fermentation I. Metabolic Pathway a. Coupled series of reactions – product of one reaction becomes substrate for another reaction b. Input = A catalyzed by enzyme l B…. i. Like in chemistry; rate reactions canceling intermediates II. Characteristics of Metabolic Pathways a. 1. One product so there’s only one to be used as substrate b. 2. So that overall Gibbs’ free energy of pathway is negative (exergonic) III. Network a. Blue circle = citric acid cycle b. Carb Metabolism = central c. Dots = nodal molecules = common intermediates IV.Redox – Reactions a. NAD+ = electron carrier i. Can accept electron from reduced molecule (AH2) 1. Produced oxidized molecule and reduced NADH b. Always happen in pairs V. Fuels a. Fats b. Carbs c. Proteins i. Only under extreme conditions d. Outputs i. ATP, NADH, Pyruvate, NADH (life cycle), NAD+
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Unformatted text preview: VI.Logic of Glycolysis a. Block represents steps = 10 b. Exergonic c. First five are endergonic to make high free energy intermediates d. Second 5 produce energy storing molecules VII. Kinase = Enzyme that adds phosphate VIII. Page 6 top i. 2 pyruvate 3-C molecules IX.Fermentation a. Anaerobic b. Restores NAD+ to continue glycolysis c. Acetaldehyde = toxin = hangover i. Reverse reaction in human breakdown of ethanol to produce acetaldehyde and acetate ii. Toxic to us and to the yeast X. Lecture Summary a. 1. One product is produced i. coupled reactions ii. thermodynamically favorable (delta G = -) b. 2. Metabolism c. 3. Input 2 ATP i. 2 ATP 2 NADH ii. phosphorylated intermediate phosphorylates ADP to make ATP d. 4. Redox e. fermentation...
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This note was uploaded on 01/27/2011 for the course BIOSC 0150 taught by Professor Lydiadaniels during the Fall '08 term at Pittsburgh.

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Glycolysis and Fermentation Notes - VI.Logic of Glycolysis...

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