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Chapter 17 Recitation

Chapter 17 Recitation - 4 Compare and contrast...

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BIOSC 0160 Recitation Worksheet March 15, 2010 1. Explain why disorders such as Sickle Cell Anemia and PKU are autosomal recessive. Caused by defects in both alleles for same gene 2. Explain the four stages of metastasis. Extends in to surrounding tissue, blood/lymphatic system, invades other tissues, angiogenesis (forming new blood vessels to tumor) 3. Suppose you have two children who are both heterozygous at a particular locus. Both parents are also heterozygous at this locus. Both children have the same sequence on each allele of the locus but have different phenotypes. How might you account for this observation? Genomic imprinting – genes differ in phenotype depending on what parent it came from
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Unformatted text preview: 4. Compare and contrast allele-specific cleavage and allele-specific oligonucleotide hybridization. Allele specific cleavage use specific restriction enzyme to recognize specific sequence and cut out normal/bad genes and look at RFLPs to see whether normal or mutant allele is present Allele-specific oligonucleotide hybridization use probes and hybridize to see if it has the normal or mutant allele (use fluorescent markers) 5. Why is it often simpler to treat human genetic disorders at the level of phenotype rather than the level of genotype? Difficult to change DNA in every cell of body...
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