ch5 - Chapter 5 Methods and Strategies of Research...

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Chapter 5 Methods and Strategies of Research Experimental Ablation - destroying part of brain and evaluating subsequent behavior; usually means destroying tissue and leaving tissue in place (not removing tissue) - Brain Lesions : experiments in which part of brain is damaged and animal’s behavior is observed - Producing Brain Lesions o Removing tissue by using vacuum pump to suck away brain tissue o Using electrical current o Excitotoxic lesions using excitatory amino acid like kainic acid which kills neurons by stimulating them to death 6-hydroxydopamine chemical selectively taken by noradrenergic or dopaminergic neurons and acts as a poison, damaging or killing them. o Sham lesions : placebo procedure that duplicates all steps of producing a brain lesions except for the one that actually causes the brain damage - Stereotaxic surgery : brain surgery using stereotaxic apparatus to position an electrode or cannula in a specified position of the brain o Bregma : junction of the sagittal and coronal sutures of the skull; often
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This note was uploaded on 01/27/2011 for the course PSYCH 326 taught by Professor Renken during the Spring '09 term at USC.

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ch5 - Chapter 5 Methods and Strategies of Research...

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