300-09%20Chap26%20Part1%20FINAL - BISC300L Wed Apr 8 2009 T...

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HOST-MICROBE INTERACTION 1 4/8/09 1 1 BISC300L Wed., Apr. 8, 2009 Human Host- Microbe Interaction Part 1 Chaps. 26-27 FINAL VERSION. print time 4/8/09 11:20 PM Please keep up. This stuff is complicated . I ! ll try to pretty much follow the order in book, but there isn ! t an easy, logical way to organize the topics, because the pathogen ! s offense and our defense and the pathogen ! s ability to overcome our defenses are so entwined. What ! s in Ch. 26 vs Ch. 27 is also pretty arbitrary. I ! ll sometimes include a few slides from Ch. 28 (microbial diseases) and Ch. 29 (viral diseases), but you ! re not responsible for the rest of Ch. 28-29. HOST-MICROBE INTERACTION 1 4/8/09 2 2 Types of human host- microbe interactions Microbes within us can be categorized on the basis of their relationship with us. Microbes can: ! Coexist without producing disease (normal microbiota). ! Cause chronic infection. ! Cause acute infection. But remember, things can change in a heartbeat. An example of this is a perforated appendix, which allows normal microbiota of the intestine to get to the abdominal cavity: this would be fatal if untreated. To remember “acute,” I think of an acute (sharp) angle. HOST-MICROBE INTERACTION 1 4/8/09 3 3 Pathogens HOST-MICROBE INTERACTION 1 4/8/09 4 4 Types of pathogens (causes of infectious disease) Organisms (cellular living things) ! Bacteria ! Protists ((protozoans) ! Fungi ! Invertebrate animals, especially worms, flukes and insects Subcellular agents ! Viruses ! Prions ! Viroids Prion diseases were in the Viruses 2 PPT file. Viroids have, so far, been found only in plants. An insect infestion that is still a problem in the US is pubic “crabs,” which are actually lice. We ! re not going to go thru Chap. 28 (covering many specific microbial diseases) or Chap. 29 (many specific viral diseases), but I ! ll show a few slides now for each kind of pathogen. on bacterial diseases.
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HOST-MICROBE INTERACTION 1 4/8/09 5 5 Gonorrhea is caused by Neisseria gonorrhoeae (“gonococcus”) Symptoms in males may include a drip of pus from the penis. Neisseria gonorrhoeae (aka “the gonococcus”) From Black 6th ed., Fig. 20-9b and 20-10a. HOST-MICROBE INTERACTION 1 4/8/09 6 6 Fig. 26.8 Giardia , a pathogenic protist Giardia , a diplomonad, is an obligate parasite. Only the inert (and rugged) cyst form is outside the host. (blue) is an intestinal parasite. Don ! t drink the water even if you ! re hiking in the wilderness. The intestinal cell (green) is covered with cilia, which are called microvilli in the intestine. HOST-MICROBE INTERACTION 1 4/8/09 7 7 Candida albicans , a yeast LEFT: Fig. 26. . RIGHT: Black 6th, fig. 19-18, from jpg.
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300-09%20Chap26%20Part1%20FINAL - BISC300L Wed Apr 8 2009 T...

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