Final Problems - 2007

Final Problems - 2007 - UNIVERSITY OF CALIFORNIA, BERKELEY...

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UNIVERSITY OF CALIFORNIA, BERKELEY CHEM C130/MCB C100A. FINAL EXAM. December 15, 2007 INSTRUCTOR: John Kuriyan and Bryan Krantz THE TIME LIMIT FOR THIS EXAMINATION IS 2 HOURS and FIFTY MINUTES SIGNATURE: Please SIGN your name ( in indelible ink ) on the line above. YOUR NAME: Please PRINT your name ( in indelible ink ) on the line above (& on the top right hand corner of every page). Also, please write all of your answers as legibly as possible . PLEASE CIRCLE THE NAME OF THE GSI FROM WHOM YOU WILL PICK UP YOUR GRADED MID-TERM EXAM: Rachel Bernstein Padma Gunda Katie Thoren James Fraser This exam consists of 10 questions. The points for each question are indicated below, for a total of 100 points. This exam counts for 400 points out of the final score of 1100 for the course, and so your score on this exam will be multiplied by 4.0 when the final score is calculated. Question Part (A) Part (B) Total 1. _____(6) _____(4) ______(10) 2. _____(6) _____(4) ______(10) 3. _____(4) _____(6) ______(10) 4. _____(5) _____(5) ______(10) 5. _____(6) _____(4) ______(10) 6. _____(6) _____(4) ______(10) 7. _____(5) _____(5) ______(10) 8. _____(5) _____(5) ______(10) 9. _____(6) _____(4) ______(10) 10. _____(6) _____(4) ______(10)
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PRINT NAME _____________________ Questions 1 (Q1.A.i) 1 pt. Which groove of B-form DNA is best used by DNA binding proteins to recognize DNA sequence. Circle your answer. Major or Minor (Q1.A.ii) 1 pt. DNA cannot adopt the A-form double helix structure. Circle your answer. True or False (Q1.A.iii) 1 pt. RNA can adopt complex tertiary structures. Circle which feature(s) of RNA allow for this to occur. (a) Metal ion binding (b) The 3’ OH group (c) Chemically modified bases (d) The base uracil (e) Tetraloop formation (Q1.A.iv) 1 pt. List all amino acid(s) that do not have chiral centers: (Q1.A.v) 1 pt. List all amino acid(s) which are positively charged at pH 5 but not at pH 8: (Q1.A.vi) 1 pt. D-amino acids are found in proteins synthesized through the central dogma. Circle your answer. True or False (Q1.B) 4 pts. If the two strands of DNA double helix are able to be replicated in opposite directions (i.e., one in the 5’ 3’ direction, and one in the 3’ 5’ direction), would you have to postulate the existence of a new high energy compound? If so, what would the chemical structure of this compound be? Clearly explain your answer.
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_____________________ Question 2 (Q2.A) 6 pts. Alpha-helices are isolated from three proteins of the same molecular weight, ~8000 Da. For each helix, only the six listed amino acids are found: (Helix from Protein 1) Lys, Asp, Leu, Phe, Ile, Ser (Helix from Protein 3) Arg, Asp, Glu, Ser, Asn, Lys (Helix from Protein 4) Leu, Trp, Ala, Phe, Ala, Val (Q2.A. i) 3 pts. Which helix likely forms the most stable and well defined tertiary structure in a water-soluble protein. Explain your reasoning. (Q2.A.ii) 3 pts.
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This note was uploaded on 01/27/2011 for the course MCB 100A taught by Professor Kuryian during the Spring '09 term at Berkeley.

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Final Problems - 2007 - UNIVERSITY OF CALIFORNIA, BERKELEY...

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