Final Problems - 2006 - CHEM C130/MCB C100A. FINAL EXAM....

Info iconThis preview shows pages 1–4. Sign up to view the full content.

View Full Document Right Arrow Icon
CHEM C130/MCB C100A. FINAL EXAM. FALL 2006. UC Berkeley. YOUR NAME:___________________________ Page 1 of 22 UNIVERSITY OF CALIFORNIA, BERKELEY CHEM C130/MCB C100A.FINAL EXAM. December 14, 2006 INSTRUCTOR: John Kuriyan THE TIME LIMIT FOR THIS EXAMINATION IS 2 HOURS and FIFTY MINUTES SIGNATURE: ________________________________________________________________ Please SIGN your name ( in indelible ink ) on the line above. YOUR NAME: ________________________________________________________________ Please PRINT your name ( in indelible ink hand corner of every page). Also, please write all of your answers as legibly as possible . PLEASE CIRCLE THE NAME OF THE GSI FROM WHOM YOU WILL PICK UP YOUR GRADED MID-TERM EXAM: Natasha Keith Kyle Simonetta Jonas Lee James Fraser Allen Liu This exam consists of 10 questions. The points for each question are indicated below, for a total of 100 points. This exam counts for 400 points out of the final score of 1100 for the course, and so your score on this exam will be multiplied by 4.0 when the final score is calculated. Question Part (A) Part (B) Part (C) Part (D) Total 1. _____(4) _____(6) xxxxx xxxxx ______(10) 2. _____(4) _____(2) _____(4) xxxxx ______(10) 3. _____(3) _____(3) _____(4) xxxxx ______(10) 4. _____(4) _____(2) _____(4) xxxxx ______(10) 5. _____(4) _____(3) _____(3) xxxxx ______(10) 6. _____(2) _____(2) _____(2) _____(4) ______(10) 7. _____(2) _____(4) _____(4) xxxxx ______(10) 8. _____(6) _____(4) xxxxx xxxxx ______(10) 9. _____(5) _____(5) xxxxx xxxxx ______(10) 10. _____(6) _____(4) xxxxx xxxxx ______(10)
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
CHEM C130/MCB C100A. FINAL EXAM. FALL 2006. UC Berkeley. YOUR NAME:___________________________ Page 2 of 22 Question 1. (10 points total) Q1A (4 points). Shown below are two oxygen binding isotherms, labeled A and B. One isotherm is for hemoglobin and one is for myoglobin. Q1A (i) Which one, A or B, is the hemoglobin isotherm? Explain how you made your choice. (2 points) Q1A (ii) A solution containing hemoglobin is treated so as to remove all the bisphosphoglycerate (BPG). On the diagram above, sketch the resulting binding isotherm for BPG-free hemoglobin. Explain briefly the mechanism by which BPG alters the binding isotherm of hemoglobin. (2 points)
Background image of page 2
Page 3 of 22 Question 1, continued. (B) (6 points) Shown below is the binding isotherm for a ligand binding to a protein: Q1B(i) Does the protein exhibit positive or negative cooperativity? Explain the basis for your answer. (2 points) Q1B(ii) Estimate roughly the difference in standard binding free energy ( ΔΔ G o ), at 300K, in kJ mol -1 between the ligand and the protein at very low ligand concentration and at very high ligand concentration. That is, calculate the value of:
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 4
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 22

Final Problems - 2006 - CHEM C130/MCB C100A. FINAL EXAM....

This preview shows document pages 1 - 4. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online