TT1 2010 - Page 1 of 6 Extracellular Dynamics and...

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Page 1 of 6 Extracellular Dynamics and Associated Pathologies Term Test 1, October 13, 2010, 3:10-4:30 P.M Student Name:________________________________________ Student Number:______________________________________ Total of 30 points worth 30% of the final mark Multiple choice questions are worth one point each. Enter your answers on the scantron. 1) With respect to the mechanisms of targeting secretory proteins to the endoplasmic reticulum membrane, which of the following statements are false ? 1) The signal peptide is a transient extension of the N-terminus secretory proteins. 2) The amino acid sequence of signal peptides is highly conserved. 3) Charged amino acids are not found in signal peptides. 4) Leucine and phenylalanine residues are often found in signal peptides. 5) SRP54 contains the signal sequence-binding activity of SRP. A) 1&2 C) 3&4 D) 4&5 E) 1&5 2) With respect to the translocation of single-pass secretory proteins across the ER membrane, which of the following statements are false ? 1) GTP hydrolysis induces a conformational change that promotes the release of SRP. 2) Signal peptide cleavage occurs on the cytoplasmic side of the ER membrane. 3) Signal peptides trigger the initiation of mRNA translation in the cytosol. 4) SRP is release only after the ribosome has bound to the translocator. 5) Signal peptides serve as a start-transfer signal. A) 1&2 C) 3&4 D) 4&5 E) 1&5 3) With respect to the supramolecular composition of collagen fibrils in connective tissues, which of the following heterofibril combinations are correct ? 1) α1 (I) 2 α 2(I) 1 and α 1(V) 2 α 2(V) 2) α 1(I) 1 α 2(I) 2 and α 1(V) 2 α 2(V) 3) α 1(I) 1 a2(I) 2 and α 1(IV) 2 α 2(IV) 4) α 1(II) 2 a 2 (I) 1 and α 1(1X) α 2(IX) α 3(IX) 5) α 1(II) 3 and α 1(1X) α 2(IX) α 3(IX) A) 1&2 B) 2&3 C) 3&4 D) 4&5 E) 1&5
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Page 2 of 6 Extracellular Dynamics and Associated Pathologies Term Test 1, October 13, 2010, 3:10-4:30 P.M 4) With respect to type I collagen synthesis and fibril assembly, which of the following statements are correct ? 1) Removal of N-propeptides precedes the removal of the C-terminal propeptides. 2) Removal of the propeptides increases the solubility of the collagen molecules. 3) Trans-cis isomerization precedes triple helix assembly.
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This note was uploaded on 01/28/2011 for the course CSB 327 taught by Professor Ringuette during the Fall '09 term at University of Toronto- Toronto.

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TT1 2010 - Page 1 of 6 Extracellular Dynamics and...

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