4_printout - Announcements review Lecture 4 Remember Keep...

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Announcements / review Lecture 4 Remember: Keep current with the textbook reading (see syllabus online). Reading for today: pages 113-115, 132-134 Reading for Monday: pages 115-121 Assigned problems: N&C: Ch.4: #1 Yesterday: Peptide bond Proteins – what they are, how to purify them for experimental study Primary structure Today: How are protein structures determined? (By scientists!) Types of forces important for structure. (This is how nature “determines” structures!)
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Why is the structure of a protein important? Protein structure => protein function You ʼ re a scientist who wants to know how a protein works….. Example: HIV protease – for drug design: Metaphor: Car engine If you know the structure, do you automatically know how the protein works?
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How to determine the 3D structure of a protein? Fundamental problem: Typical atom size: Wavelength of visible light: Two experimental methods that give atomic -level resolution:
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X-ray diffraction : Need to grow protein crystals .
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