lecture18 - 20-1Purine NucleotidesPurine NucleotidesOrigin...

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Unformatted text preview: 20-1Purine NucleotidesPurine NucleotidesOrigin of the atoms in purinesnumbers show the order in which each atom or group of atoms is addedNCNCCCNCNglycineN10-formyl-THFglutamineaspartateCO2N10-formyl-THF145263720-2IMP to AMPIMP to AMPHNNNNOribose 5'-PInosine 5'-P (IMP)Aspartate + GTPGDP + PiNNNNribose 5'-P-OOC-CH2- CH-COO-NHAdenylosuccinateNNNNribose 5'-PNH2Adenosine 5'-P (AMP)FumarateGTP here instead of ATP20-3IMP to GMPIMP to GMPHNNNNOribose 5'-PInosine 5'-P (IMP)HNNHNNOribose 5'-POXanthosine 5'-P (XMP)HNNNNOribose 5'-PH2NGuanosine 5'-P (GMP)NAD+ + H2ONADH + H+Gln + ATP + H2OGlu + ADP + PPiATP here instead of GTP20-4Regulation of ATP, GTP synthesisRegulation of ATP, GTP synthesisIMPXMPGMPGDPGTPAMPADPATPAdenylosuccinatefeedbackinhibitionRibose 5-PAccumulation of each product can feedback to limit biosynthesis20-5Purine CatabolismPurine CatabolismHNNNNOH2NRibosePGMPHNNNNOOHHXanthineNNNNNH2RibosePAMPH2NCONH2H2NCOH2NCOCOHO-UreaUreaGlyoxylate++20-6...
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lecture18 - 20-1Purine NucleotidesPurine NucleotidesOrigin...

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