{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

lecture18 - 20-1Purine NucleotidesPurine...

Info iconThis preview shows pages 1–6. Sign up to view the full content.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: 20-1Purine NucleotidesPurine Nucleotides•Origin of the atoms in purines•numbers show the order in which each atom or group of atoms is addedNCNCCCNCNglycineN10-formyl-THFglutamineaspartateCO2N10-formyl-THF145263720-2IMP to AMPIMP to AMPHNNNNOribose 5'-PInosine 5'-P (IMP)Aspartate + GTPGDP + PiNNNNribose 5'-P-OOC-CH2- CH-COO-NHAdenylosuccinateNNNNribose 5'-PNH2Adenosine 5'-P (AMP)FumarateGTP here instead of ATP20-3IMP to GMPIMP to GMPHNNNNOribose 5'-PInosine 5'-P (IMP)HNNHNNOribose 5'-POXanthosine 5'-P (XMP)HNNNNOribose 5'-PH2NGuanosine 5'-P (GMP)NAD+ + H2ONADH + H+Gln + ATP + H2OGlu + ADP + PPiATP here instead of GTP20-4Regulation of ATP, GTP synthesisRegulation of ATP, GTP synthesisIMPXMPGMPGDPGTPAMPADPATPAdenylosuccinatefeedbackinhibitionRibose 5-PAccumulation of each product can feedback to limit biosynthesis20-5Purine CatabolismPurine CatabolismHNNNNOH2NRibosePGMPHNNNNOOHHXanthineNNNNNH2RibosePAMPH2NCONH2H2NCOH2NCOCOHO-UreaUreaGlyoxylate++20-6...
View Full Document

{[ snackBarMessage ]}

Page1 / 15

lecture18 - 20-1Purine NucleotidesPurine...

This preview shows document pages 1 - 6. Sign up to view the full document.

View Full Document Right Arrow Icon bookmark
Ask a homework question - tutors are online