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newlecture12 - Electron Transport Chain 2 O 2 4 H 4 e 2 H2...

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17-1 Electron Transport Chain Electron Transport Chain 2 2 H 2 O + 4 H + + 4 e - O 2
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17-2 Electron Transport Chain Electron Transport Chain Proton gradient across inner mitochondrial membrane
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17-3 the proton gradient establishes a voltage gradient the proton and voltage gradients together provide the mechanism to couple electron transport with phosphorylation of ADP + ADP P i ATP + H 2 O Electron Transport Chain Electron Transport Chain
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17-4 Electron Transport Chain Electron Transport Chain The electron transport chain this oxidation results in formation of 2.5 ATP this oxidation results in formation of 1.5 ATP
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17-5 Reduction Potentials Reduction Potentials A useful way to look at electron transport is to consider the change in free energy associated with the movement of electrons from one carrier to another if we have two electron carriers, for example NADH and coenzyme Q, are electrons more likely to be transferred from NADH to coenzyme Q, or vice versa? what we need to know is the reduction potential reduction potential for each carrier a carrier of high reduction potential will tend to be reduced if it is paired with a carrier of lower reduction potential
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17-6 Reduction Potentials Reduction Potentials Table 17.1 Standard reduction potentials increasing reduction potentials
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17-7 NADH-CoQ oxidoreductase electrons are passed from NADH ( low ) to FMN ( high ) N N H 3 C H 3 C N NH O O CH 2 CH 2 OPO 3 2 - Flavin mononucleotide (FMN) N N H 3 C H 3 C N NH O O CH 2 CH 2 OPO 3 2 - Dihydroflavin mononucleotide (FMNH 2 ) H H 2 H +   +   2 e - ( CHOH) 3 ( CHOH) 3 Protons picked up and Delivered to inner mitochondrial space
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17-8 Complex I Complex I electrons are then passed to the iron-sulfur clusters finally, electrons are passed to coenzyme Q (also called ubiquinone) CH 3 O CH 3 O ( CH 2 CH= CCH 2 ) n CH 3 O O CH 3 H Coenzyme Q (oxidized form) CH 3 O CH 3 O ( CH 2 CH= CCH 2 ) n CH 3 OH OH CH 3 H Coenzyme QH 2 (reduced form) reduction oxidation 2 H +   +   2 e - + Protons picked up and Delivered to inner mitochondrial space
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17-9 Complex I Complex I the overall equation for the reaction of complex I is this transfer drives proton pumping this transfer of electrons is strongly exergonic and is sufficient to drive phosphorylation of ADP
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