3500Ch17 - Chapter 17 Preparing for the Citric Acid Cycle...

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Click to edit Master subtitle style Chapter 17 – Preparing for the Citric Acid Cycle A.K.A. – The TCA cycle or Krebs cycle The final common pathway for oxidation of fuel molecules. Hans Adolf Krebs - Nobel Prize 1953
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The Citric Acid Cycle Amphibolic (both catabolic and anabolic ) Aerobic catabolism of carbohydrates, lipids and amino acids Intermediates are starting points for many biosynthetic reactions. Amino acids, nucleotide bases, cholesterol Enzymes of the cycle are in the mitochondria (eukaryotes) or the cytosol (bacteria)
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Overall – TCA cycle oxidizes acetyl groups to two molecules of CO2
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Energy in the citric acid cycle Energy of the oxidation reactions is largely conserved as reducing power NAD+ NADH Ubiquinone (Q) Ubiquinol (QH2)
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Entry into citric acid cycle Can happen at various points Most common entry is: Acetyl CoA
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Acetyl CoA Formed by the breakdown of Glycogen (via pyruvate & pyruvate dehydrogenase) Fats (a main source, the most direct route) Amino acids
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Intermembrane space Where the citric acid cycle mainly occurs
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3500Ch17 - Chapter 17 Preparing for the Citric Acid Cycle...

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