3500Ch19Pt1 - glycolysis TCA Electron transport 22...

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22 Electron transport TCA glycolysis
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Oxidative Phosphorylation
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55 Mitochondria Outer membrane : Very few proteins (one is porin) Porin forms channels which allows free diffusion of typically of anionic compounds and water soluble metabolites Inner membrane : Protein rich (protein:lipid ratio = 4:1 by mass) Contains the electron transport chain and ATP synthase Permeable to H20, O2, CO2 Barrier to protons and larger polar/ionic substances Highly folded (cristae) to increase surface area Humans contain the equivalent of 3 football fields of inner mitochondrial membrane
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66 Mitochondria continued Intermembrane space : Equal to the cytosol due to porins (is the space between membranes) The matrix : Contains the TCA enzymes (except SDH complex) Contains FA oxidation enzymes Contains the pyruvate dehydrogenase complex Protein concentration nears 500 mg /ml, and is almost a gel Also contains metabolites, inorganic ions, NAD+, NADP+ It is energetically unfavorable to pump in anions due to neg.
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